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. 2019 Jun 24;9:9139. doi: 10.1038/s41598-019-45579-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Validation of the 4-GES in gene expression data set GSE37642, consisting of 379 cytogenetically heterogeneous AML patients. (A) Cut-off value for stratification of AML patients into 4-GES^low (blue) and 4-GES^high (red) was calculated by maximally selected rank statistics. (B) Kaplan Meier curves for overall survival of 379 AML patients classified as 4-GES^low (blue) and 4-GES^high (red). (C) Kaplan Meier curves for overall survival of 107 ELN favourable, 174 ELN intermediate I/II and 86 ELN adverse risk AML patients stratified into 4-GES^low (blue) and 4-GES^high (red). Statistical significance was calculated using the log rank test and p-values were adjusted for multiple testing according to Altman et al.⁵⁸. (D) Kaplan Meier curves for overall survival of AML patients stratified into favourable, intermediate, and adverse based on ELN 2010 classification (left) and ELN 2010 + 4-GES classification (right). ELN, European Leukemia Net.