Table 1. Functional characterizations of FEZF1-AS1 in multiple human cancers.

Cancer types	Expression	Role	Biological function	Related genes	References
Pancreatic cancer	Up-regulated	Oncogenic	Cell proliferation, apoptosis, migration, invasive, progression, Warburg effect, cell cycle control	HIF-1α, VEGF, miR-142, EGFR, AKT, p-AKT, miR-107, miR-133a, FEZF1	[20,21]
Ovarian cancer	Up-regulated	Oncogenic	Cell proliferation, apoptosis	STAT3, p-STAT3	[23]
Nasopharyngeal carcinoma	Up-regulated	Oncogenic	Cell proliferation, migration, invasive, cell cycle control, EMT	P21, CyclinD1, E-cadherin, Vimentin, N-cadherin, Wnt/β-catenin	[25]
Hepatocellular carcinoma	Up-regulated	Oncogenic	Cell proliferation, migration, invasive, cell cycle control, EMT	JAK/STAT3, E-cadherin, N-cadherin, Vimentin	[28]
Cervical cancer	Up-regulated	Oncogenic	No description	No description	[32,33]
Colorectal cancer	Up-regulated	Oncogenic	Cell proliferation, apoptosis, migration, invasive, progression, Warburg effect, cell cycle control	PKM2, STAT3, FEZF1MCL1, BIRC5, CCND1, BCL2L1, CDH1, MMP2, MMP9	[16,35]
Multiple myeloma	Up-regulated	Oncogenic	Cell proliferation, cell cycle control, apoptosis	miR-610, AKT3	[37]
Breast cancer	Up-regulated	Oncogenic	Cell proliferation, migration, invasive, progression	miR-30a, Nanog, Oct4, SOX2	[39]
Osteosarcoma	Up-regulated	Oncogenic	Cell proliferation, migration, invasive, progression	miR-4443, NUPR1	[41]
Non-small-cell lung cancer	Up-regulated	Oncogenic	Cell proliferation, migration, invasive, progression, EMT cell cycle control	CDK2, CDK4, CDK6, cleaved-caspase3, total-caspase3, cleaved-caspase9, total-caspase9, cleaved-PARP, P57, LSD1, EZH2, Slug, total-PARP, Vimentin, HUR, FEZF1, ZO-1, Snail, Twist, AXIN1, E-cadherin, β-catenin TCF4	[44–47]
Gastric cancer	Up-regulated	Oncogenic	Cell proliferation, apoptosis, progression, cell cycle control	Wnt/β-catenin, p21, CDK2, CDK4, CDK6, LSD1, CyclinD1, SP1, E-cadherin, H3K4me3	[49–51]