Table 3. Signaling pathway enrichment analysis of differentially expressed genes in PABC.

DEGs	Biological pathway	Count	P-value	Mapped gene names
Up-regulated	Fatty acid activation	2	0.00	ACSBG1, SL6
	FGF signaling pathway	3	0.00	STAT5B, CG1, MP9
	LPA receptor mediated events	4	0.00	PLCG1, XN, DCY7, MP9
	Cell-extracellular matrix interactions	2	0.00	PARVB, XN
	CXCR4-mediated signaling events	5	0.00	STAT5B, LCG1, XN, TPN7, MP9
	EGFR interacts with phospholipase C-gamma	2	0.01	PLCG1, DCY7
	Signaling by EGFR	3	0.02	PLCG1, XN, DCY7
	Chemokine receptors bind chemokines	2	0.02	CXCR5, XCL13
	E-cadherin signaling in the nascent adherens junction	5	0.02	STAT5B, LCG1, DCY7, TGB7, MMP9
	IL6-mediated signaling events	2	0.03	IRF1, TNFSF11
Down-regulated	Activation of DNA fragmentation factor	2	0.00	HMGB1, KPNA1
	Apoptosis induced DNA fragmentation	2	0.00	HMGB1, KPNA1
	Valine degradation I	2	0.00	ACADSB, HIBADH
	Apoptotic execution phase	3	0.00	HMGB1, KPNA1, DNM1L
	Notch signaling pathway	4	0.00	AR, NCOR1, RAB11A, MIB1
	Branched-chain amino acid catabolism	2	0.00	ACADSB, HIBADH
	PIP3 activates AKT signaling	2	0.01	AKT1S1, CREB1
	Glutamate biosynthesis II	1	0.01	GLUD1
	PI-3K cascade	2	0.02	AKT1S1, CREB1
	AKT-mediated inactivation of FOXO1A	1	0.02	CREB1

Count: the number of enriched genes in each term.