TABLE 2.
Cumulative percentage MIC distribution and ECOFF values of cefepime and cefepime-enmetazobactam against Gram-negative pathogens collected worldwide in the United States and Europe during 2014 and 2015
| Species (n) and drug | Cumulative % isolates at or below various MICs (μg/ml)a
|
ECOFF (μg/ml) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | >64 | ||
| Enterobacteriaceae | |||||||||||||||
| All (1,696) | |||||||||||||||
| Cefepime | 2.7 | 30.2 | 62.9 | 72.9 | 78.2 | 81.1 | 82.5 | 83.7 | 85.3 | 87.0 | 89.2 | 91.5 | 93.6 | 100 | |
| Cefepime-enmetazobactam | 2.7 | 39.6 | 77.1 | 87.7 | 92.6 | 94.8 | 96.2 | 96.8 | 97.3 | 98.1 | 98.5 | 99.0 | 99.4 | 100 | |
| E. coli (697) | |||||||||||||||
| Cefepime | 2.3 | 27.3 | 64.3 | 75.5 | 80.9 | 83.2 | 84.4 | 85.8 | 87.8 | 89.8 | 92.3 | 94.7 | 97.1 | 100 | 0.12 |
| Cefepime-enmetazobactam | 3.6 | 44.0 | 86.1 | 95.0 | 98.9 | 99.3 | 99.7 | 99.9 | 99.9 | 99.9 | 99.9 | 100 | |||
| E. coli ESBL genotypeb (109) | |||||||||||||||
| Cefepime | 0.9 | 0.9 | 3.7 | 6.4 | 13.8 | 23.9 | 36.7 | 52.3 | 67.0 | 81.7 | 100 | ||||
| Cefepime-enmetazobactam | 0.9 | 19.3 | 69.7 | 90.8 | 98.2 | 98.2 | 99.1 | 99.1 | 99.1 | 99.1 | 99.1 | 100 | |||
| K. pneumoniae (799) | |||||||||||||||
| Cefepime | 3.1 | 35.2 | 65.1 | 73.5 | 77.5 | 79.5 | 80.6 | 80.9 | 81.2 | 82.7 | 85.0 | 87.6 | 90.0 | 100 | 0.12 |
| Cefepime-enmetazobactam | 2.3 | 40.3 | 76.2 | 85.0 | 89.4 | 92.4 | 93.2 | 93.7 | 95.0 | 96.4 | 97.2 | 98.1 | 99.0 | 100 | |
| K. pneumoniae ESBL genotypeb (102) | |||||||||||||||
| Cefepime | 2.0 | 3.9 | 6.9 | 16.7 | 30.4 | 42.2 | 52.9 | 100 | |||||||
| Cefepime-enmetazobactam | 8.8 | 42.2 | 66.7 | 77.5 | 89.2 | 92.2 | 93.1 | 98.0 | 100 | ||||||
| Cefepime-tazobactam | 1.0 | 8.8 | 32.4 | 49.0 | 60.8 | 68.6 | 76.5 | 85.3 | 88.2 | 92.2 | 95.1 | 96.1 | 97.1 | 100 | |
| K. pneumoniae KPC genotypec (45) | |||||||||||||||
| Cefepime | 2.2 | 11.1 | 28.9 | 46.7 | 100 | ||||||||||
| Cefepime-enmetazobactam | 4.4 | 6.7 | 13.3 | 24.4 | 42.2 | 57.8 | 71.1 | 86.7 | 100 | ||||||
| E. aerogenes (100) | |||||||||||||||
| Cefepime | 5.0 | 35.0 | 62.0 | 69.0 | 81.0 | 91.0 | 96.0 | 97.0 | 99.0 | 100 | 0.12 | ||||
| Cefepime-enmetazobactam | 2.0 | 35.0 | 64.0 | 84.0 | 94.0 | 97.0 | 99.0 | 100 | |||||||
| E. cloacae (100) | |||||||||||||||
| Cefepime | 7.0 | 37.0 | 55.0 | 62.0 | 69.0 | 71.0 | 79.0 | 86.0 | 88.0 | 90.0 | 91.0 | 91.0 | 100 | 0.25 | |
| Cefepime-enmetazobactam | 7.0 | 34.0 | 63.0 | 74.0 | 81.0 | 92.0 | 96.0 | 96.0 | 97.0 | 98.0 | 98.0 | 98.0 | 100 | ||
| P. aeruginosa (297) | |||||||||||||||
| Cefepime | 0.3 | 1.3 | 2.7 | 12.1 | 45.1 | 64.3 | 79.5 | 92.3 | 95.6 | 98.3 | 100 | 16 | |||
| Cefepime-enmetazobactam | 0.7 | 1.0 | 2.0 | 12.1 | 44.8 | 67.3 | 82.8 | 93.6 | 96.3 | 98.3 | 100 | ||||
a
MIC90 values are in boldface.
b
Isolates containing an ESBL gene with or without OXA-48 and/or AmpC genes.
c
Isolates containing a KPC gene with or without ESBL, OXA-48, and/or AmpC genes.