TABLE 2.
Fluoroquinolones by MIC category, SNP, corresponding amino acid, and MTBDRsl probe
| Fluoroquinolone | MIC (mg/liter) [mode (median)] | SNP | AAa | Corresponding Hain LPA probe |
|---|---|---|---|---|
| Gatifloxacin | 0.0625 (0.0625) | Wild type | ||
| Low-level MIC | 0.25 (0.5) | 90GTG | A90V (Val) | gyrAMUT1 |
| 94GCC | D94A (Ala) | gyrAMUT3A | ||
| High-level MIC | 1.5 (1.5) | 88TGC | G88C (Cys) | |
| 91CCG | S91P (Pro) | gyrAMUT2 | ||
| 94TAC | D94Y (Tyr) | gyrAMUT3B | ||
| 94AAC | D94N (Asn) | gyrAMUT3B | ||
| 94GGC | D94G (Gly) | gyrAMUT3C | ||
| 94CAC | D94H (His) | gyrAMUT3D | ||
| Levofloxacin | 0.375 (0.375) | Wild type | ||
| Low-level MIC | 2.5 (2.5) | 90GTG | A90V (Val) | gyrAMUT1 |
| 91CCG | S91P (Pro) | gyrAMUT2 | ||
| 94GCC | D94A (Ala) | gyrAMUT3A | ||
| High-level MIC | 3.5 (3.5) | 88TGC | G88C (Cys) | |
| 94AAC | D94N (Asn) | gyrAMUT3B | ||
| 94TAC | D94Y (Tyr) | gyrAMUT3B | ||
| 94GGC | D94G (Gly) | gyrAMUT3C | ||
| 94CAC | D94H (His) | gyrAMUT3D | ||
| Moxifloxacin | 0.125 (0.125) | Wild type | ||
| Low-level MIC | 0.5 (0.5) | 91CCG | S91P (Pro) | gyrAMUT2 |
| 94TAC | D94Y (Tyr) | gyrAMUT3B | ||
| High-level MIC | 1.0 (1.0) | 88TGC | G88C (Cys) | |
| 90GTG | A90V (Val) | gyrAMUT1 | ||
| 94GCC | D94A (Ala) | gyrAMUT3A | ||
| 94AAC | D94N (Asn) | gyrAMUT3B | ||
| 94GGC | D94G (Gly) | gyrAMUT3C | ||
| 94CAC | D94H (His) | gyrAMUT3D | ||
| Ofloxacin | 1.0 (1.0) | Wild type | ||
| Low-level MIC | 3.0 (3.0) | 91CCG | S91P (Pro) | gyrAMUT2 |
| High-level MIC | 5.0 (5.0) | 88TGC | G88C (Cys) | |
| 90GTG | A90V (Val) | gyrAMUT1 | ||
| 94GCC | D94A (Ala) | gyrAMUT3A | ||
| 94TAC | D94Y (Tyr) | gyrAMUT3B | ||
| 94AAC | D94N (Asn) | gyrAMUT3B | ||
| 94GGC | D94G (Gly) | gyrAMUT3C | ||
| 94CAC | D94H (His) | gyrAMUT3D |
a
AA, amino acid.