FIG 4.

Hearing capacity assessed 3 weeks after acute pneumococcal meningitis. Representative ABR recordings from a mock-infected rat (A) with a hearing threshold of 35 dB compared to that of an infected rat (B) with an elevated hearing threshold of 65 dB. Perceived sound intensities are indicated with dashed lines. Infected animals receiving combined-adjuvant therapy (n = 25) showed a trend toward improved hearing thresholds compared to those of animals receiving CRO monotherapy (n = 23) (C). Combined-adjuvant therapy significantly reduced hearing loss in mildly infected animals (n = 10) compared to results with CRO monotherapy (n = 9) (D). *, P < 0.05.