TABLE 2.

Amino acid substitutions in PBP4 and a nucleotide deletion in the promoter region of the pbp4 gene compared with MICs of penicillin, imipenem, and ampicillin^d

^aDeletion of a single A residue in a string of seven A residues upstream of a putative −35 region for the pbp4 gene described previously by Rice et al. (13).

^bThe amino acid sequences of PBP4 of E. faecalis isolates were compared with that of the reference E. faecalis strain ATCC 29212.

^cMICs designating intermediate resistance and resistance are indicated by boldface type and gray-shaded areas, respectively.

^d“O” indicates that the specified sequence variant was identified. Abbreviations: CC, clonal complex; nPBD, non-penicillin-binding domain; NE, not evaluated; PBD, penicillin-binding domain.