TABLE 1.
Summary of P. falciparum isolates and nonsynonymous polymorphisms in the Kelch13 observed
| Country and area | Collection yr(s) | Sample source (ref.) | No. of isolates | Wild-type sequences (n [%]) | NS-SNPsa (n [%]) | Resistant mutants (n) | NS-SNP |
|---|---|---|---|---|---|---|---|
| PNG | |||||||
| Madang | 1980s | (55) | 13 | 13 (100) | 0 (0) | 0 | NAb |
| Bougainville | 1998–1999 | Community survey (56) | 61 | 61 (100) | 0 (0) | 0 | NA |
| Solomon Islands | |||||||
| Guadalcanal | 1987 | Culture adapted (57) | 6 | 6 (100) | 0 (0) | 0 | NA |
| Malaita | 2008 | Therapeutic efficacy study | 74 | 71 (96) | 3 (4) | 0 | I465Fc , F673Yc , M460Kc |
| Vanuatu | |||||||
| Tanna | 2008 | Community survey (58) | 18 | 17 (94) | 1 (6) | 0 | S477F, T677Ic |
| Total | 169 | 165 (97.6) | 4 (2.4) | 0 |
a
NS-SNPs, nonsynonymous sequence polymorphisms.
b
NA, not applicable.
c
Novel sequence polymorphisms.