TABLE 2.
Summary of P. vivax isolates and nonsynonymous sequence polymorphisms (NS-SNP) in Kelch12 observed
| Country and area | Collection yr | Sample source (ref.) | No. of isolates | Wild-type sequences (n [%]) | NS-SNPsa (n [%]) | Resistant mutants (n) | NS-SNP |
|---|---|---|---|---|---|---|---|
| Solomon Islands | |||||||
| Malaita | 2008 | Therapeutic efficacy study | 26 | 24 (92) | 2 (8) | 0 | V652L |
| Vanuatu | |||||||
| Tanna | 2008 | Community survey (58) | 11 | 11 (100) | 0 (0) | 0 | NA |
| Epi Island | 2011 | Therapeutic efficacy study | 22 | 21 (95) | 1 (5) | 0 | I537V |
| Total | 59 | 56 (95) | 3 (5) | 0 |
a
NS-SNP, nonsynonymous sequence polymorphisms.