TABLE 5.
Activity of antimicrobial agents tested against Staphylococcus aureus, Enterobacteriaceae, and Acinetobacter baumannii-Acinetobacter calcoaceticus species complex submitted to the SENTRY Program, 1997–2016
| Organism/antimicrobial agent (no. tested) | MIC50 (mg/liter) | MIC90 (mg/liter) | CLSIa
|
EUCASTa
|
||||
|---|---|---|---|---|---|---|---|---|
| %S | %I | %R | %S | %I | %R | |||
| Staphylococcus aureus (56,579) | ||||||||
| Ceftaroline (16,658) | 0.25 | 1 | 96.2 | 3.7 | 0.1 | 96.2 | 3.7 | 0.1 |
| Ceftobiprole (23,214) | 0.5 | 2 | 99.4 | 0.6 | ||||
| Dalbavancin (36,161) | 0.06 | 0.06 | >99.9b | 99.7 | 0.3 | |||
| Daptomycin (37,814) | 0.25 | 0.5 | 99.9 | 99.9 | 0.1 | |||
| Linezolid (53,595) | 2 | 2 | >99.9 | <0.1 | >99.9 | <0.1 | ||
| Teicoplanin (56,570) | ≤2 | ≤2 | >99.9c | 98.8 | 1.2 | |||
| Tigecycline (37,085) | ≤0.12 | 0.25 | 99.8b | 99.8 | 0.2 | |||
| Vancomycin (56,575) | 1 | 1 | 99.9 | 0.1 | 0.0 | 99.9 | 0.1 | |
| Enterobacteriaceae (107,617) | ||||||||
| Amikacin (107,561) | ≤4 | ≤4 | 97.4 | 1.3 | 1.3 | 95.5 | 2.0 | 2.6 |
| Ampicillin-sulbactam (74,048) | 16 | >16 | 49.4 | 17.1 | 33.5 | 49.4 | 50.6 | |
| Aztreonam (107,580) | ≤0.12 | 16 | 86.5 | 1.6 | 11.9 | 84.0 | 2.5 | 13.5 |
| Cefepime (107,581) | ≤0.5 | 4 | 89.3 | 3.0d | 7.7 | 87.5 | 3.3 | 9.1 |
| Ceftazidime-avibactam (31,672) | 0.12 | 0.25 | 99.7 | 0.3 | 99.7 | 0.3 | ||
| Ceftriaxone (107,575) | ≤0.25 | >8 | 83.5 | 0.8 | 15.7 | 83.5 | 0.8 | 15.7 |
| Ciprofloxacin (107,567) | ≤0.5 | >2 | 80.9 | 1.7 | 17.5 | 76.6 | 1.9 | 21.5 |
| Colistin (54,476) | ≤0.5 | >4 | 88.0 | 12.0 | ||||
| Doxycycline (59,912) | 2 | >8 | 66.5 | 9.1 | 24.5 | |||
| Gentamicin (107,561) | ≤2 | >8 | 87.9 | 1.1 | 11.0 | 86.7 | 1.2 | 12.1 |
| Imipenem (107,322) | ≤0.5 | 1 | 95.2 | 3.1 | 1.7 | 98.3 | 1.1 | 0.6 |
| Levofloxacin (107,571) | ≤0.5 | >4 | 82.5 | 2.4 | 15.1 | 79.2 | 2.3 | 18.5 |
| Meropenem (107,529) | ≤0.12 | ≤0.12 | 98.8 | 0.2 | 1.0 | 99.0 | 0.3 | 0.7 |
| Minocycline (56,100) | 2 | >8 | 77.2 | 8.5 | 14.3 | |||
| Piperacillin-tazobactam (107,301) | 2 | 16 | 90.0 | 4.4 | 5.6 | 86.8 | 3.2 | 10.0 |
| Tetracycline (107,577) | ≤4 | >8 | 64.0 | 2.8 | 33.2 | |||
| Tigecycline (68,141) | 0.25 | 1 | 98.4b | 1.4 | 0.2 | 94.9 | 3.5 | 1.6 |
| Tobramycin (107,579) | 0.5 | >8 | 86.4 | 3.1 | 10.5 | 83.6 | 2.8 | 13.6 |
| Trimethoprim-sulfamethoxazole (107,571) | ≤0.5 | >1 | 74.7 | 25.3 | 74.7c | |||
| P. aeruginosa (14,562) | ||||||||
| Amikacin (14,559) | ≤4 | 16 | 90.0 | 2.4 | 7.6 | 86.1 | 4.0 | 10.0 |
| Aztreonam (14,558) | 8 | >16 | 66.7 | 13.9 | 19.4 | 1.7 | 78.9 | 19.4 |
| Cefepime (14,559) | 4 | >16 | 79.9 | 10.0 | 10.1 | 79.9 | 20.1 | |
| Ceftazidime (14,557) | ≤2 | >16 | 77.7 | 4.9 | 17.4 | 77.7 | 22.3 | |
| Ceftazidime-avibactam (3,911) | 2 | 8 | 93.4 | 6.6 | 93.4 | 6.6 | ||
| Ciprofloxacin (14,559) | ≤0.5 | >2 | 74.8 | 3.0 | 22.2 | 71.0 | 29.0 | |
| Colistin (7,107) | 1 | 2 | 99.3 | 0.7 | 99.3 | 0.7 | ||
| Doripenem (9,112) | 0.5 | >4 | 78.9 | 8.0 | 13.1 | 71.5 | 7.3 | 21.1 |
| Gentamicin ((14,557) | ≤2 | >8 | 79.8 | 2.8 | 17.4 | 79.8 | 20.2 | |
| Imipenem (14,534) | 1 | >8 | 75.3 | 4.7 | 20.0 | 80.0 | 7.2 | 12.7 |
| Levofloxacin (14,557) | ≤0.5 | >4 | 72.9 | 4.1 | 23.0 | 66.2 | 33.8 | |
| Meropenem (14,556) | 0.5 | >8 | 77.5 | 6.2 | 16.3 | 77.5 | 11.8 | 10.8 |
| Piperacillin-tazobactam (14,549) | 8 | >64 | 73.8 | 11.3 | 14.9 | 73.8 | 26.2 | |
| Polymyxin B (8,855) | ≤1 | 2 | 99.6 | 0.4 | <0.1 | |||
| Tobramycin (14,558) | 0.5 | >8 | 82.8 | 0.7 | 16.6 | 82.8 | 17.2 | |
| Acinetobacter baumannii-Acinetobacter calcoaceticus complex (5,333) | ||||||||
| Amikacin (5,332) | >32 | >32 | 45.7 | 4.2 | 50.1 | 42.6 | 3.1 | 54.3 |
| Ampicillin-sulbactam (4,056) | >16 | >16 | 36.5 | 11.8 | 51.7 | |||
| Cefepime (5,332) | >16 | >16 | 35.5 | 11.1 | 53.4 | |||
| Ceftazidime (5,332) | >16 | >16 | 32.8 | 5.8 | 61.5 | |||
| Ciprofloxacin (5,332) | >2 | >2 | 32.4 | 0.6 | 67.0 | 32.4 | 67.6 | |
| Colistin (3,124) | ≤0.5 | 2 | 96.9 | 3.1 | 96.9 | 3.1 | ||
| Doxycycline (3,238) | ≤1 | >8 | 67.4 | 1.5 | 31.1 | |||
| Gentamicin (5,324) | >8 | >8 | 39.0 | 5.4 | 55.6 | 39.0 | 61.0 | |
| Imipenem (5,333) | 2 | >8 | 55.3 | 3.1 | 41.6 | 55.3 | 5.9 | 38.8 |
| Levofloxacin (5,332) | >4 | >4 | 34.6 | 8.3 | 57.1 | 32.3 | 1.1 | 66.7 |
| Meropenem (5,326) | 2 | >8 | 52.0 | 4.1 | 43.8 | 52.0 | 8.9 | 39.1 |
| Minocycline (3,098) | ≤1 | >8 | 81.5 | 8.4 | 10.1 | |||
| Piperacillin-tazobactam (5,320) | >64 | >64 | 30.8 | 9.4 | 59.8 | |||
| Tetracycline (5,178) | 8 | >8 | 42.4 | 13.2 | 44.4 | |||
| Tigecycline (3,688) | 0.5 | 2 | ||||||
| Tobramycin (5,330) | 4 | >8 | 52.4 | 3.2 | 44.4 | 52.4 | 47.6 | |
| Trimethoprim-sulfamethoxazole (5,331) | >1 | >1 | 41.7 | 58.3 | 41.7c | |||
a
Criteria as published by CLSI (40) and EUCAST (41), the latter for comparison only. S, sensitive; I, intermediate; R, resistant.
b
Breakpoints from FDA package insert (42).
c
Dilution range did not extend far enough to determine whether the data represented intermediate or resistant status, so only the susceptible percentage is displayed.
d
Intermediate data interpreted as susceptible-dose dependent.