FIG 7.

Antiviral effects of compound 10 against DENV-2 in vivo. A129 mice (5 to 8 mice per group) were infected with DENV-2 (1 × 10³ PFU) on day 0, and viral loads were quantified with a plaque assay on day 6 postinfection. Compound 10 was administered daily (10 mg/kg), via the i.p. route, as a pretreatment (from day 0 to day 6) or therapeutically (from day 2 to day 6). Viral loads recovered from serum (A), spleen (B), liver (C), and brain (D) were determined. The median values for viral loads are represented as lines. #, P < 0.05, in comparison to the vehicle-treated infected group.