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Comparison of HCV, JEV, and DENV-2 active sites bound to 7-deaza-7-fluoro-2′-C-methyl-ATP. The RNA template and primer strands are shown in green and blue, respectively. The Mn2+ ions are shown as purple spheres. The active site sequences from a stamp structural alignment for HCV, JEV, and DENV-2 are provided, and residues in direct contact with the incoming NTP are highlighted in yellow.
