TABLE 5.
Simulated exposure and PK/PD breakpointsa
| Simulated dose (mg/day) | Mean fAUC0–24 (SD), mg ⋅ h/liter | PK/PD breakpoint (mg/liter)b |
|
|---|---|---|---|
| fAUC0–24/MIC 130 | fAUC0–24/MIC 360 | ||
| Levofloxacin | |||
| 750 | 84.98 (17.88) | 0.25 | 0.125 |
| 1,000 | 113.61 (23.65) | 0.50 | 0.125 |
| 1,250 | 142.76 (29.41) | 0.50 | 0.25 |
| 1,500 | 168.97 (35.33) | 0.50 | 0.25 |
| 1,750 | 199.27 (41.56) | 1.00 | 0.25 |
| Moxifloxacin | |||
| 400 | 26.23 (8.37) | 0.125 | 0.03 |
| 600 | 39.32 (12.57) | 0.125 | 0.06 |
| 800 | 52.15 (16.72) | 0.25 | 0.06 |
| 1,000 | 65.06 (20.17) | 0.25 | 0.06 |
| 1,200 | 77.72 (25.11) | 0.25 | 0.125 |
a
PK/PD, pharmacokinetic/pharmacodynamic. fAUC0–24, area under the free concentration-time curve from time zero to 24 h.
b
The PK/PD breakpoint is the highest MIC when at least 90% target attainment is achieved.