TABLE 3.
MICs for the synergistically interacting antifungal and nonantifungal ophthalmic agents natamycin and timolol
| Strain | MIC (μg/ml) of each agent alone |
MIC (μg/ml) of each agent in the combination |
FICI | Avg FICI | ||
|---|---|---|---|---|---|---|
| Natamycin | Timolol | Natamycin | Timolol | |||
| F. solani | ||||||
| 132.02 | 16 | >6,800 | 8 | 425 | 0.53 | 0.52 |
| 4 | 3,400 | 0.50 | ||||
| 06-0487 | 32 | >6,800 | 16 | 213 | 0.52 | 0.45 |
| 8 | 1,700 | 0.38 | ||||
| 06-0330 | 32 | >6,800 | 16 | 213 | 0.50 | 0.41 |
| 8 | 850 | 0.31 | ||||
| 06-0133 | 32 | >6,800 | 16 | 53 | 0.50 | 0.41 |
| 8 | 850 | 0.31 | ||||
| 06-0111 | 32 | >6,800 | 16 | 213 | 0.52 | 0.52 |
| 06-0110 | 32 | >6,800 | 16 | 53 | 0.50 | 0.41 |
| 8 | 850 | 0.31 | ||||
| F. oxysporum | ||||||
| 06-0342 | 32 | >6,800 | 16 | 213 | 0.52 | 0.41 |
| 8 | 850 | 0.31 | ||||
| 06-0197 | 16 | >6,800 | 8 | 53 | 0.50 | 0.44 |
| 4 | 1,700 | 0.38 | ||||