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. 2019 Jun 24;63(7):e02505-18. doi: 10.1128/AAC.02505-18

TABLE 4.

MICs for the synergistically interacting antifungal and nonantifungal ophthalmic agents natamycin and 5-fluorouracil

Strain MIC (μg/ml) of each agent alone
MIC (μg/ml) of each agent in the combination
FICI Avg FICI
Natamycin 5-Fluorouracil Natamycin 5-Fluorouracil
F. solani
    132.02 16 1,250 8 78 0.56 0.59
     2 625 0.63
    06-0487 16 2,500 8 156 0.56 0.56
     4 625 0.50
     2 1,250 0.63
    06-0330 32 2,500 16 10 0.50 0.40
     8 156 0.31
     4 625 0.38
    06-0133 32 2,500 16 10 0.50 0.34
     8 78 0.28
     4 313 0.25
     2 625 0.31
    06-0111 32 2,500 16 10 0.50 0.44
     8 156 0.31
     4 625 0.38
     2 1,250 0.56
    06-0110 32 2,500 16 10 0.50 0.40
     8 156 0.31
     4 625 0.38
F. oxysporum
    06-0342 32 5,000 16 78 0.52 0.40
     8 313 0.31
     4 1,250 0.38
    06-0197 16 5,000 8 156 0.53 0.55
4 1,250 0.50
2 2,500 0.63