TABLE 4.
MICs for the synergistically interacting antifungal and nonantifungal ophthalmic agents natamycin and 5-fluorouracil
| Strain | MIC (μg/ml) of each agent alone |
MIC (μg/ml) of each agent in the combination |
FICI | Avg FICI | ||
|---|---|---|---|---|---|---|
| Natamycin | 5-Fluorouracil | Natamycin | 5-Fluorouracil | |||
| F. solani | ||||||
| 132.02 | 16 | 1,250 | 8 | 78 | 0.56 | 0.59 |
| 2 | 625 | 0.63 | ||||
| 06-0487 | 16 | 2,500 | 8 | 156 | 0.56 | 0.56 |
| 4 | 625 | 0.50 | ||||
| 2 | 1,250 | 0.63 | ||||
| 06-0330 | 32 | 2,500 | 16 | 10 | 0.50 | 0.40 |
| 8 | 156 | 0.31 | ||||
| 4 | 625 | 0.38 | ||||
| 06-0133 | 32 | 2,500 | 16 | 10 | 0.50 | 0.34 |
| 8 | 78 | 0.28 | ||||
| 4 | 313 | 0.25 | ||||
| 2 | 625 | 0.31 | ||||
| 06-0111 | 32 | 2,500 | 16 | 10 | 0.50 | 0.44 |
| 8 | 156 | 0.31 | ||||
| 4 | 625 | 0.38 | ||||
| 2 | 1,250 | 0.56 | ||||
| 06-0110 | 32 | 2,500 | 16 | 10 | 0.50 | 0.40 |
| 8 | 156 | 0.31 | ||||
| 4 | 625 | 0.38 | ||||
| F. oxysporum | ||||||
| 06-0342 | 32 | 5,000 | 16 | 78 | 0.52 | 0.40 |
| 8 | 313 | 0.31 | ||||
| 4 | 1,250 | 0.38 | ||||
| 06-0197 | 16 | 5,000 | 8 | 156 | 0.53 | 0.55 |
| 4 | 1,250 | 0.50 | ||||
| 2 | 2,500 | 0.63 | ||||