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. 2019 Jun 24;63(7):e00420-19. doi: 10.1128/AAC.00420-19

TABLE 3.

Times to detection of Gram-positive organisms recovered from BacT/Alert or Bactec aerobic (AE) and anaerobic (ANA) Plus media at each antimicrobial drug concentration tested in blood culture triplicates

Organism and drug Concentrationa BacT/Alert Plus media
 Bactec Plus media
Recovery (no. of replicates/total)
 Mean TTDb
ΔTTDc
Recovery
 Mean TTDb
ΔTTDc
AE ANA AE ANA AE ANA AE ANA AE ANA AE ANA
E. faecalis
    Ampicillin Cmax 3/3 3/3 18.75 17.79 9.08 8.06 2/3 1/3 15.28 16.50 3.17 4.23
C/2 3/3 3/3 11.28 11.30 1.61 1.57 3/3 3/3 13.97 14.35 1.86 2.08
C/4 3/3 3/3 10.95 10.32 1.28 0.59 3/3 3/3 12.28 13.29 0.17 1.02
No drug 3/3 3/3 9.67 9.73 3/3 3/3 12.11 12.27
    Linezolid Cmax 3/3 3/3 9.66 9.81 0.20 −0.11 3/3 3/3 11.30 11.52 −0.01 0.14
C/2 3/3 3/3 9.28 9.27 −0.18 −0.65 3/3 3/3 11.25 11.54 −0.06 0.16
C/4 3/3 3/3 9.15 9.24 −0.31 −0.68 3/3 3/3 10.50 11.38 −0.81 0.00
No drug 3/3 3/3 9.46 9.92 3/3 3/3 11.31 11.38
    Tigecycline Cmax 3/3 3/3 10.53 11.38 1.04 2.16 3/3 3/3 13.39 13.45 2.03 2.26
C/2 3/3 3/3 9.32 9.84 −0.17 0.62 3/3 3/3 11.93 12.29 0.57 1.10
C/4 3/3 3/3 9.21 9.27 −0.28 0.05 3/3 3/3 11.09 11.44 −0.27 0.25
No drug 3/3 3/3 9.49 9.22 3/3 3/3 11.36 11.19
    Vancomycin Cmax 3/3 3/3 10.99 10.70 1.31 0.72 3/3 3/3 12.85 13.71 0.75 1.62
C/2 3/3 3/3 10.86 10.42 1.18 0.44 3/3 3/3 12.39 13.40 0.29 1.31
C/4 3/3 3/3 10.90 10.66 1.22 0.68 3/3 3/3 12.28 13.20 0.18 1.11
No drug 3/3 3/3 9.68 9.98 3/3 3/3 12.10 12.09
Methicillin-susceptible S. aureus
    Ceftaroline Cmax 3/3 3/3 11.82 12.20 0.89 2.73 0/3 0/3 >120 >120 NAd NA
C/2 3/3 3/3 10.94 10.45 0.01 0.98 3/3 3/3 16.93 16.77 5.45 4.32
C/4 3/3 3/3 10.36 9.71 −0.57 0.24 3/3 3/3 14.34 13.78 2.86 1.33
No drug 3/3 3/3 10.93 9.47 3/3 3/3 11.48 12.45
    Daptomycin Cmax 3/3 3/3 10.20 9.54 −0.02 0.48 3/3 3/3 12.76 12.62 1.33 0.29
C/2 3/3 3/3 10.30 9.25 0.08 0.19 3/3 3/3 11.77 12.33 0.34 0.00
C/4 3/3 3/3 10.40 9.16 0.18 0.10 3/3 3/3 11.43 12.40 0.00 0.07
No drug 3/3 3/3 10.22 9.06 3/3 3/3 11.43 12.33
    Linezolid Cmax 3/3 3/3 11.70 10.49 1.52 1.24 3/3 3/3 11.97 13.08 0.61 1.08
C/2 3/3 3/3 11.90 10.17 1.72 0.92 3/3 3/3 12.11 13.21 0.75 1.21
C/4 3/3 3/3 10.46 9.83 0.28 0.58 3/3 3/3 11.46 12.38 0.10 0.38
No drug 3/3 3/3 10.18 9.25 3/3 3/3 11.36 12.00
    Tigecycline Cmax 3/3 3/3 10.94 10.90 −0.18 0.88 3/3 2/3 12.28 12.85 0.66 0.29
C/2 3/3 3/3 10.89 9.90 −0.23 −0.12 3/3 3/3 11.49 13.30 −0.13 0.74
C/4 3/3 3/3 11.07 9.89 −0.05 −0.13 3/3 3/3 11.34 12.95 −0.28 0.39
No drug 3/3 3/3 11.12 10.02 3/3 3/3 11.62 12.56
    Vancomycin Cmax 3/3 2/3 15.52 13.41 3.51 3.51 3/3 2/3 25.49 36.32 12.53 23.71
C/2 3/3 3/3 14.57 13.24 3.34 3.34 3/3 3/3 21.45 23.94 8.49 11.33
C/4 3/3 3/3 13.92 12.05 2.15 2.15 3/3 3/3 18.23 18.82 5.27 6.21
No drug 3/3 3/3 11.19 9.90 3/3 3/3 12.96 12.61
Methicillin-resistant S. aureus
    Ceftaroline Cmax 3/3 3/3 13.88 19.84 1.32 9.21 3/3 3/3 17.64 21.78 4.34 7.27
C/2 3/3 3/3 13.84 17.60 1.28 6.97 3/3 3/3 17.35 18.28 4.05 3.77
C/4 3/3 3/3 13.23 16.14 0.67 5.51 3/3 3/3 15.96 16.80 2.66 2.29
No drug 3/3 3/3 12.56 10.63 3/3 3/3 13.30 14.51
    Ciprofloxacin Cmax 3/3 3/3 13.62 16.32 1.93 6.00 3/3 3/3 13.63 14.84 0.08 −0.06
C/2 3/3 3/3 12.51 15.08 0.82 4.76 3/3 3/3 13.37 14.77 −0.18 −0.13
C/4 3/3 3/3 12.55 14.20 0.86 3.88 3/3 3/3 13.32 14.32 −0.23 −0.58
No drug 3/3 3/3 11.69 10.32 3/3 3/3 13.55 14.90
    Gentamicin Cmax 3/3 3/3 13.85 16.66 2.10 6.29 3/3 3/3 13.17 14.29 −0.37 0.10
C/2 3/3 3/3 12.68 16.40 0.93 6.03 3/3 3/3 13.29 14.07 −0.25 −0.12
C/4 3/3 3/3 12.55 15.40 0.80 5.03 3/3 3/3 13.20 14.08 −0.34 −0.11
No drug 3/3 3/3 11.75 10.37 3/3 3/3 13.54 14.19
    Linezolid Cmax 3/3 3/3 12.80 12.02 1.37 1.37 3/3 3/3 18.57 19.52 5.27 4.44
C/2 3/3 3/3 12.90 11.00 0.35 0.35 3/3 3/3 17.65 18.54 4.35 3.46
C/4 3/3 3/3 11.46 11.09 0.44 0.44 3/3 3/3 16.20 18.47 2.90 3.39
No drug 3/3 3/3 11.98 10.65 3/3 3/3 13.30 15.08
    Tigecycline Cmax 3/3 3/3 15.25 14.55 2.33 4.15 3/3 3/3 17.94 18.01 4.27 2.90
C/2 3/3 3/3 14.46 13.88 1.54 3.48 3/3 3/3 18.15 17.34 4.48 2.23
C/4 3/3 3/3 13.92 13.22 1.00 2.82 3/3 3/3 17.12 15.42 3.45 0.31
No drug 3/3 3/3 12.92 10.40 3/3 3/3 13.67 15.11
    Vancomycin Cmax 3/3 3/3 16.19 20.27 4.15 9.69 3/3 3/3 25.26 38.05 11.63 22.48
C/2 3/3 3/3 15.46 14.80 3.42 4.22 3/3 3/3 22.44 26.61 8.81 11.04
C/4 3/3 3/3 14.00 13.89 1.96 3.31 3/3 3/3 20.33 19.22 6.70 3.65
No drug 3/3 3/3 12.04 10.58 3/3 3/3 13.63 15.57
S. pneumoniae
    Ciprofloxacin Cmax 3/3 3/3 12.42 12.24 1.19 0.99 3/3 3/3 13.55 13.51 0.48 0.13
C/2 3/3 3/3 12.20 11.26 0.97 0.01 3/3 3/3 13.17 13.47 0.10 0.09
C/4 3/3 3/3 11.88 11.24 0.65 −0.01 3/3 3/3 13.05 13.36 −0.02 −0.02
No drug 3/3 3/3 11.23 11.25 3/3 3/3 13.07 13.38
    Linezolid Cmax 3/3 3/3 11.26 19.51 0.19 7.13 3/3 3/3 13.66 16.40 0.53 2.42
C/2 3/3 3/3 11.89 13.83 0.82 1.45 3/3 3/3 13.29 14.81 0.16 0.83
C/4 3/3 3/3 11.74 12.41 0.67 0.03 3/3 3/3 13.19 15.12 0.06 1.14
No drug 3/3 3/3 11.07 12.38 3/3 3/3 13.13 13.98
    Penicillin G Cmax 3/3 3/3 12.50 14.95 1.63 2.52 3/3 2/3 16.71 17.40 2.60 2.95
C/2 3/3 3/3 11.32 12.52 0.45 0.09 3/3 3/3 15.13 15.88 1.02 1.43
C/4 3/3 3/3 11.63 12.26 0.76 −0.17 3/3 3/3 15.03 15.30 0.92 0.85
No drug 3/3 3/3 10.87 12.43 3/3 3/3 14.11 14.45
    Vancomycin Cmax 3/3 0/3 11.32 >120 0.14 NA 0/3 0/3 >120 >120 NA NA
C/2 3/3 2/3 11.22 12.25 0.04 0.22 1/3 0/3 19.50 >120 7.06 NA
C/4 3/3 2/3 11.28 12.19 0.10 0.16 3/3 2/3 16.43 17.35 3.99 4.25
No drug 3/3 3/3 11.18 12.03 3/3 3/3 12.44 13.10
a

For each antibiotic tested, Cmax, C/2, and C/4 are those specified in Table 1.

b

For each organism-antibiotic combination tested, the mean time to detection (TTD) was calculated by summing the TTDs of single blood culture replicates. TTDs are rounded to the nearest decimal.

c

For each organism-antibiotic combination tested, ΔTTD is the difference of TTD of the antibiotic-containing blood culture by that of the antibiotic-free blood culture (no-drug control). Boldface values are the clinically significant ΔTTD values (≥3 h) obtained for some organism-antibiotic combinations at the Cmax, C/2, and/or C/4 tested.

d

NA, not applicable (no organism growth in any bottles).