TABLE 1.
Activities of fidaxomicin and comparative agents versus 1,889 isolates of Clostridium difficile from 2013 to 2016
| Antibiotic | MIC range (μg/ml) | MIC50 (μg/ml) | MIC90 (μg/ml) | % Resistant |
|
|---|---|---|---|---|---|
| CLSI | EUCAST | ||||
| Fidaxomicin | 0.004–1 | 0.25 | 0.5 | NA | NA |
| Rifaximin | ≤0.004 to >4 | 0.03 | 0.06 | NA | NA |
| Rifampin | ≤0.004 to >4 | ≤0.004 | 0.008 | NA | 29.8 |
| Tigecycline | ≤0.06–1 | 0.12 | 0.25 | 0.0 | 1.0 |
| Vancomycin | ≤0.25–8 | 1 | 2 | NA | 6.5 |
| Imipenem | ≤0.12–16 | 4 | 8 | 6.2 | NA |
| Moxifloxacin | ≤0.5 to >16 | 2 | 16 | 23.2 | 23.2 |
| Metronidazole | ≤0.06–4 | 0.25 | 1 | 0.0 | 1.3 |
| Clindamycin | ≤0.5 to >16 | 4 | 16 | 27.6 | NA |
| Chloramphenicol | ≤0.5–16 | 4 | 8 | 0.0 | NA |