TABLE 2.

Comparison of %fT>MIC values achieved with CTB and CLA at different MICs in humans and mice

Drug	Species	%fT>MIC for MIC (mg/liter) of:								fAUC0–24 (mg·h/liter)
		0.063	0.125	0.25	0.5	1	2	4	8
CTB	Humana	100.00	100.00	100.00	100.00	93.33	68.75	35.00	0.00
	Mouseb	100.00	100.00	100.00	100.00	91.25	71.25	32.08	0.00
CLA	Humanc	100.00	83.75	67.50	52.50	37.50	21.25	0.00	0.00	24.07
	Moused	95.00	85.00	72.50	56.25	38.75	18.75	0.00	0.00	26.28

^aHuman exposures estimated based on the population pharmacokinetic parameters of CTB for a dose of 400 mg p.o. q8h.

^bMouse exposure estimated based on best-fit pharmacokinetic parameters of CTB alone or in combination with CLA in infected mice.

^cHuman exposures estimated based on the population pharmacokinetic parameters of CLA for a dose of 187 mg p.o. q8h.

^dMouse exposure estimated based on best-fit pharmacokinetic parameters of CLA in combination with CTB in infected mice.