TABLE 3.
CLA %fT>CT of 0.5 mg/liter required to achieve net stasis and 1-log killing against Enterobacteriaceae isolates
| Isolate (MIC [mg/liter])a | CLA %fT>0.5 mg/liter required to achieve: |
R2 | |
|---|---|---|---|
| Stasis | 1-log reductionb | ||
| EC 513 (4) | 22.35 | 39.58 | 0.9264 |
| EC 501 (0.5) | 12.55 | 16.51 | 0.6092 |
| EC 512 (4) | 0.00 | 12.49 | 0.4158 |
| KP 620 (0.25) | 0.61 | NA | 0.8746 |
| KP 622 (0.5) | 35.52 | NA | 0.7456 |
| EC 506 (1) | 1.40 | NA | 0.8755 |
| KP 626 (1) | 2.71 | NA | 0.9765 |
| EC 511 (2) | 7.15 | NA | 0.1032 |
| KP 631 (8) | 46.56 | 68.76 | 0.7769 |
| EC 514 (4) | 7.31 | NA | 0.8658 |
| KP 632 (8) | 75.67 | NA | 0.7925 |
| Median | 7.31 | 28.04c | 0.7925 |
| IQR | 1.40–35.52 | 13.5–61.47c | |
| Composite (all isolates) | 20.59 | 91.63 | 0.4732 |
a
MIC based on the combination of CTB-CLA (2:1 ratio). IQR, interquartile range.
b
NA, target not achieved.
c
Based on the estimate from 4 isolates only (EC 513, EC 501, EC 512, and KP 631).