TABLE 2.
MICs and synergy activity of RFX and TOB against P. aeruginosa strains
| Strain | Typea | MIC RFX | MIC RFX in combination | FIC RFX | MIC TOB | MIC TOB in combination | FIC TOB | ΣFIC | Activityb |
|---|---|---|---|---|---|---|---|---|---|
| PAO1 | NM | 16 | 4 | 0.25 | 2 | 0.25 | 0.125 | 0.375 | ++ |
| PAO581 | M | 16 | 4 | 0.25 | 2 | 0.5 | 0.25 | 0.5 | + |
| PAO581 | NM revertant | 16 | 4 | 0.25 | 2 | 0.5 | 0.25 | 0.5 | + |
| CF001 | M | 16 | 4 | 0.25 | 2 | 0.5 | 0.25 | 0.5 | + |
| CF010 | M | 8 | 2 | 0.25 | 2 | 0.5 | 0.25 | 0.5 | + |
| CF003 | NM | 4 | 1 | 0.25 | 2 | 0.25 | 0.125 | 0.375 | + |
a
NM, nonmucoid; M, mucoid.
b
Lowest ΣFIC measure: synergy (++) ≤ 0.5; additive (+) 0.5 < to ≤ 1; indifferent (±) 1< to ≤ 4; antagonism (−) > 4 (22).