TABLE 2.
Omadacycline pharmacodynamic target exposures for each S. aureus strain in the murine thigh infection model
| Organism or measurement | MIC (mg/liter) | Growth in untreated controls (log10 CFU) | 24-h static dose (mg/kg) | Stasis AUC/MIC | 24-h 1-log kill dose (mg/kg) | 1-log kill AUC/MIC |
|---|---|---|---|---|---|---|
| ATCC 29213 | 0.25 | 2.63 | 11.67 | 29.64 | 24.20 | 58.83 |
| SMITH | 0.25 | 2.78 | 20.88 | 51.13 | 128.00 | 302.51 |
| MW2 | 0.5 | 2.49 | 18.78 | 23.12 | 44.07 | 52.49 |
| R2527 | 0.5 | 2.05 | 17.54 | 21.68 | 52.32 | 62.06 |
| 6538P | 0.25 | 1.96 | 8.43 | 22.05 | 19.94 | 48.95 |
| ATCC 25923 | 0.25 | 2.22 | 8.72 | 22.71 | 25.40 | 61.63 |
| ATCC 33591 | 0.5 | 2.47 | 12.84 | 16.19 | 47.62 | 56.61 |
| WIS-1 | 0.5 | 2.31 | 10.80 | 13.80 | 35.45 | 42.48 |
| LSI 1848 | 0.5 | 1.89 | 16.44 | 20.41 | 53.00 | 62.86 |
| 307109 | 0.5 | 2.84 | 13.12 | 16.52 | 26.57 | 32.17 |
| Mean | 2.33 | 13.92 | 23.73 | 45.66 | 78.06 | |
| Median | 2.31 | 12.98 | 21.87 | 39.76 | 57.72 | |
| SD | 0.34 | 4.28 | 10.61 | 31.42 | 79.47 |