TABLE 2.
Details of 310 carbapenemase- and non-carbapenemase-producing bacterial organisms tested in clinical positive blood cultures by the NG-Test Carba 5 assay
| Species | Carbapenemase status (no. positive/total)a
and relative meropenem susceptibility |
|||||||
|---|---|---|---|---|---|---|---|---|
| KPCb
|
OXA-48-like |
VIMb
|
Noncarbapenemase |
|||||
| Type | MIC (μg/ml) | Type | MIC (μg/ml) | Type | MIC (μg/ml) | Type | MIC (μg/ml) | |
| Klebsiella pneumoniae (total no. positive) | 123 | 1 | 2 | 184 | ||||
| KPC-2 (4/4) | 8 to >64 | OXA-48 (1/1) | 16 | VIM-1 (0/1) | 8 | CTX-M-15 (0/72) | ≤0.125 | |
| KPC-3 (98/99) | 8 to >64 | VIM-1 + CTX-M-15 (1/1) | 4 | SHV-12 (0/12) | ≤0.125 | |||
| KPC-3 + CTX-M-15 (20/20) | 4 to >64 | None (0/100) | ≤0.125 | |||||
a
The NG-Test Carba 5 immunochromatographic assay is capable of detecting the following variants from the 5 carbapenemases (KPC, OXA-48-like, VIM, IMP, and NDM) included as targets: KPC-2/-3, NDM-1/-4/-5/-6/-7/-9, IMP-1/-8/-11, VIM-1/-2/-4/-19, and OXA-48/-181/-204/-232/-244/-517/-519/-535. No organisms produced IMP or NDM carbapenemases detectable by the assay.
b
The NG-Test Carba 5 immunochromatographic assay failed to detect 2 (1 KPC-3 and 1 VIM-1) of the carbapenemases produced in the study.