TABLE 1.
MICs of selected anti-TB compounds against M. tuberculosis H37Rv and corresponding interaction profiles with TBI-166 assessed by checkerboard methoda
| Compound A | MIC (μg/ml), alone/in combination |
Interaction profile with TBI-166 |
||
|---|---|---|---|---|
| MICA | MICTBI-166 | FIC index | Outcome | |
| INH | 0.05/0.0125 | 0.06/0.06 | 1.25 | Indifferent |
| RFP | 0.05/0.05 | 0.06/0.015 | 1.25 | Indifferent |
| BDQ | 0.04/0.01 | 0.06/0.03 | 0.75 | Indifferent |
| PMD | 0.07/0.0044 | 0.06/0.03 | 0.56 | Indifferent |
| LZD | 0.30/0.075 | 0.06/0.03 | 0.75 | Indifferent |
a
Isoniazid, INH; rifampin, RFP; bedaquiline, BDQ; pretomanid, PMD; linezolid, LZD.