TABLE 2.

Experimental design used in study 1

Group	Drug(s)a	No. of mice sacrificed in each groupb				Total no. of mice
		D–18	D0	W4	W8
Negative control	Untreated	6	6	6	6	24
Positive control	INH+RFP+PZA			6	6	12
Single drugs	TBI-166, BDQ, PMD, PZA, LZD			30	30	60
Two-drug combinations	TBI-166+BDQ, TBI-166+PMD, TBI-166+PZA, TBI-166+LZD			24	24	48
Three-drug combinations	TBI-166+BDQ+PMD, TBI-166+BDQ+LZD, TBI-166+PMD+LZD			18	18	36
Four-drug combination	TBI-166+BDQ+PMD+LZD			6	6	12
Total no. of mice		6	6	90	90	192

^aDrugs (abbreviations) and doses: isoniazid (INH), 10 mg/kg; rifampin (RFP), 10 mg/kg; pyrazinamide (PZA), 150 mg/kg; TBI-166 (20 mg/kg); bedaquiline (BDQ), 25 mg/kg; pretomanid (PMD), 100 mg/kg; linezolid (LZD), 100 mg/kg.

^bD, day; W, week.