Table 3.
Regions of interest (ROIs) analyses.
| Brain region | Side | Cluster size | MNI coordinates | T | p | pFWE | |||
|---|---|---|---|---|---|---|---|---|---|
| x | y | z | |||||||
| Empathy for physical pain | |||||||||
| PP > NP | |||||||||
| F-CG | |||||||||
| Anterior cingulate | 587 | −2 | 26 | 46 | 6.44 | <.001 | <.001 | ||
| Anterior insula | L | 156 | −36 | 18 | 0 | 5.91 | <.001 | <.001 | |
| Anterior insula | R | 110 | 42 | 18 | −4 | 4.59 | <.001 | .001 | |
| Somatosensory cortex | L | 42 | −58 | −28 | 36 | 3.77 | <.001 | .013 | |
| F-ASD | |||||||||
| Anterior cingulate | 407 | −6 | 18 | 36 | 5.12 | <.001 | .002 | ||
| F-CG (PP > NP) > F-ASD (PP > NP) | |||||||||
| Anterior insula | L | 16 | −34 | 20 | 4 | 3.28 | <.001 | .024 | |
| Anterior insula | R | 1 | 34 | 24 | 0 | 3.12 | <.001 | .033 | |
| Empathy for social pain | |||||||||
| (SKS+NKS) > NS | |||||||||
| F-CG | |||||||||
| Anterior cingulate | 222 | −6 | 28 | 42 | 5.76 | <.001 | <.001 | ||
| Anterior insula | L | 33 | −28 | 24 | 0 | 5.49 | <.001 | <.001 | |
| Thalamus | 18 | −2 | −6 | 8 | 4.32 | <.001 | <.001 | ||
| F-ASD | |||||||||
| Anterior cingulate | 25 | −8 | 18 | 40 | 4.11 | <.001 | .005 | ||
| SKS > NKS | |||||||||
| F-CG | |||||||||
| Anterior insula | L | 3 | −28 | 24 | 2 | 2.83 | <.001 | .030 | |
| Thalamus | 23 | −4 | −6 | 6 | 3.76 | <.001 | .002 | ||
| F-ASD | |||||||||
| Anterior insula | L | 2 | −40 | 24 | 4 | 2.72 | <.001 | .039 | |
| Thalamus | 16 | −6 | −8 | 8 | 3.25 | <.001 | .006 | ||
| F-CG [(SKS+NKS) > NS] > F-ASD [(SKS+NKS) > NS] | |||||||||
| Anterior insula | L | 22 | −28 | 24 | 0 | 3.73 | <.001 | .003 | |
All statistics for the contrasts reported in the table are thresholded at p < .05, family-wise-error corrected (FWE), within regions of interest (ROIs). PP, physical pain condition; NP, no pain condition; SKS, shared knowledge social pain situations; NKS, non-shared knowledge social pain situations; NS, neutral social control situations; F-CG, non-clinical control group; F-ASD, autism spectrum disorder group.