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. 2019 May 14;14(6):1380. doi: 10.1021/acschembio.9b00298

Designed Small-Molecule Inhibitors of the Anthranilyl-CoA Synthetase PqsA Block Quinolone Biosynthesis in Pseudomonas aeruginosa

Cheng Ji, Indrajeet Sharma, Debarshi Pratihar, L Lynn Hudson, Damien Maura, Tezcan Guney, Laurence G Rahme, Everett C Pesci, James P Coleman, Derek S Tan
PMCID: PMC6591703  PMID: 31083966

During the preparation of this manuscript, Figure 2 was inadvertently altered such that the values listed on the y axes were 10-fold lower than intended. The corrected version of Figure 2 is provided. This correction does not alter the conclusions of the paper. We apologize for any confusion resulting from this error.

Figure 2.

Figure 2

Inhibition of HHQ (8 h) and PQS (20 h) quinolone production in P. aeruginosa strain PA14 (1.5 mM inhibitors). Statistical significance relative to the blank was assessed using a two-tailed unpaired Student t-test with 95% confidence intervals; *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.


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