Table 4.

Mean German semi-quantitative scoring of immunohistochemical staining in association with progression to metastasis.

Stain	Non-metastatic primary	Metastatic primary	Metastatic secondary	p-value
p-Ser-486/491 AMPKα	1.41	4.41	6.61	<0.0001***
p-Thr-172 AMPKα	1.53	2.24	2.44	0.537
AMPKα	6.03	7.83	9.91	0.007**
p-Ser-79 ACC	3.15	1.21	0.35	<0.0001***
p-Ser-872 HMG-CoAR	11.06	7.21	7.94	0.005**
p-Ser-792 Raptor	3.41	3.21	2.47	0.336

Analysis of immunohistochemical staining of primary prostate tumors and metastases. AMPKα, adenosine monophosphate (AMP)-activated protein kinase, alpha catalytic subunit; ACC, acetyl-CoA carboxylase; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase.

^**p < 0.01,

^***p <0.0001 determined by Cochran-Armitage test for trend.