Table 5.
Mean German semi-quantitative scoring of immunohistochemical staining in association with progression to castration-resistance.
| Stain | Hormone-Dependent (n=102) | Castration-Resistant (n=18) | p-value |
|---|---|---|---|
| p-Ser-486/491 AMPKα | 3.05 | 7.64 | 0.0087** |
| p-Thr-172 AMPKα | 1.95 | 2.21 | 0.824 |
| AMPKα | 7.92 | 8.00 | 0.960 |
| p-Ser-79 ACC | 2.37 | 2.29 | 0.928 |
| p-Ser-872 HMG-CoAR | 8.99 | 7.69 | 0.179 |
| p-Ser-792 Raptor | 3.22 | 2.07 | 0.097 |
Analysis of immunohistochemical staining comparing hormone-dependent and castration-resistant specimens. AMPKα, adenosine monophosphate (AMP)-activated protein kinase, alpha catalytic subunit; ACC, acetyl-CoA carboxylase; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase.
**
p < 0.01 determined by Kruskal-Wallis test.