Table 6.

Mean German semi-quantitative scoring of immunohistochemical staining of primary tumor phosphorylation and AMPKα protein expression in association with biopsy total Gleason score.

	Biopsy Total Gleason Score
	6 (n=17)	7 (n=29)	8 (n=10)	9 (n=17)	10 (n=2)	p-value
p-Ser-486/491 AMPKα	1.94	2.50	4.00	5.54	9.00	0.002**
p-Thr-172 AMPKα	1.65	2.09	2.00	2.62	3.00	0.870
AMPKα	5.71	7.27	8.25	7.46	7.50	0.843
p-Ser-79 ACC	2.06	3.27	0.00	1.46	0.00	0.078
p-Ser-872 HMG-CoAR	10.53	11.27	10.25	5.62	3.50	0.014*
p-Ser-792 Raptor	3.88	3.91	4.50	1.77	8.00	0.211

AMPKα, adenosine monophosphate (AMP)-activated protein kinase, alpha catalytic subunit; ACC, acetyl-CoA carboxylase; HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase. No statistical distinction was found between Gleason 3+4=7 and 4+3=7 prostate cancer.

^*p < 0.05;

^**p < 0.01 determined by Cochran-Armitage test for trend.