. Author manuscript; available in PMC: 2019 Jun 25.

Published in final edited form as: Prostate. 2018 Mar 26;78(10):714–723. doi: 10.1002/pros.23515

Table 7.

AMPKα cellular localization and prostate cancer progression to metastasis.

	Non-metastatic primary	Metastatic primary	Metastatic secondary	p-value
AMPKα (%)				0.009^**
Cytoplasmic only	21/30 (70.0)	33/45 (73.3)	42/45 (93.3)
Cytoplasmic and nuclear	9/30 (30.0)	12/45 (26.7)	3/45 (6.7)
p-Ser-486/491 AMPKα (%)				<0.0001^***
Cytoplasmic only	0/21 (0.0)	4/42 (9.5)	22/41 (53.7)
Cytoplasmic and nuclear	21/21 (100.0)	38/42 (90.5)	19/41 (46.3)
p-Thr-172 AMPKα (%)				0.010^*
Cytoplasmic only	11/23 (47.8)	20/37 (54.1)	32/41 (78.0)
Cytoplasmic and nuclear	12/23 (52.2)	17/37 (45.9)	9/41 (22.0)

Cytoplasmic localization with progression to metastasis. Only slides with positive staining analyzed.

p < 0.05,

^**

p < 0.01,

^***

p < 0.0001 determined by Cochran Armitage test for trend.