TABLE 2.
Testing schedule summary.
| Testing Daysa |
|||
|---|---|---|---|
| Testing | Pre–Bed Rest | Bed Rest | Post–Bed Rest |
| Standard measures | |||
| Bone densitometry | −11 | 15, 32, 48, 65 | +2, +180, +365 |
| QCT | −3 | +4, +180, +365 | |
| Echocardiography | −6, −2 | 7, 21, 31, 70 | +0, +3, +13 |
| Cardiovascular tilt test | −4 | 70 | +3 |
| Plasma volume | −6, −2 | 7 | +0, +1, +3, +6, +13 |
| Aerobic capacity | −7 | 4, 25, 46, 68 | +0, +11 |
| Vertical jump | −6, −2 | +0, +13 | |
| Isokinetic testing | −11, −5 | +2, +12 | |
| Posture and balance | −12, −6, −2 | +0, +1, +6, +13 | |
| Reflex testing | −10, −4, −1 | 5, 20, 70 | +0, +3, +6 |
| Nutritional assessment | −10, −3 | 7, 14, 21, 28 | +0, +5 |
| Immunologic assessment | −10 | 28 | +0, +5 |
| Investigator measures | |||
| Treadmill locomotion/dynamic visual acuity test | −12, −6, −2 | +0, +1, +6, +13 | |
| Fine motor control test | −12, −6, −2 | +0, +1, +6, +13 | |
| FTT | −12, −6, −2 | +0, +1, +6, +13 | |
| Muscle performance measures | −20, −12, −6, −2 | +0, +1, +6, +13 | |
| Muscle size—MRI | −5 | 3, 7, 11, 15, 22, 29, 36, 53, 69 | +3, +6, +10 |
| Muscle size—ultrasound scanning | −5 | 3, 7, 11, 15, 22, 29, 36, 53, 69, | +3, +6, +10 |
| Muscle biopsy | 3, 57 | ||
| Mood and fatigue questionnaires | −20, −1 | Weekly | +0, +13 |
| Glucose tolerance test | −20, −1 | 37, 66 | +12 |
| Nasal patency | −10, −8, −6, −4, −2, −1 | 21 tests | +0, +1, +2, +4, +7, +10, +12, +180 |
| Odorant test | −10, −8, −6, −4, −2, −1 | 21 tests | +0, +1, +2, +4, +7, +10, +12, +180 |
| Smell acuity tests | −1 | 1, 3, 37, 65 | +2, +12 |
| Food questionnaires | Daily | Daily | Daily |
| Vision exam | −13, −5 | Weekly | +2, +9 |
| Optical coherence tomography and fundus photography | −13, −5 | 38 | +2, +9 |
| Behavioral assessment | −11, −7 | 8,50, 65 | +5, +11 |
| Brain MRI and fMRI | −12, −8 | 8, 50, 67 | +0, +6, +13 |
| Personality test | −21 | ||
| Journal entries | Daily | Daily | Daily |
| Psychological dimensions survey | Daily | Daily | Daily |
| Outgoing debrief | +12 | ||
fMRI, functional MRI.
a
A negative sign indicates the number of days before bed rest; a positive sign indicates the number of days after bed rest; no sign indicates the number of days in bed rest. Day +0 is the day subjects stood up from bed rest.