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. 2019 Jun 24;19:619. doi: 10.1186/s12885-019-5813-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Analysis of ZFP423 and retinoic acid effects in SDHC-loss MEFs. a Representative ZFP423 immunostain images of stable SDHC-loss (Exp) and hemizygous control (Ctl) MEF lines. b Analysis of ZFP423 mean cellular immunostain intensity using CellProfiler automated image analysis approach. c Analysis of ZFP423 subcellular localization using CellProfiler automated image analysis. d Relative RNA-seq gene expression quantification for known retinoic acid receptors and transcriptional co-activators. Comparisons indicated by asterisks are statistically significant by a two-sided heteroscedastic t-test (p < 0.05). e Alamar blue cell viability analysis following 6-d exposure of MEF cells to retinoic acid. f Relative RNA-seq gene expression quantification for Bcl2