Table 4.
Diagnostic indices of the diagnostic techniques using sWGA assay as reference
| Technique | TP | TN | FP | FN | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) |
|---|---|---|---|---|---|---|---|---|
| Microscopy | 57 | 632 | 0 | 82 |
41.0 32.7–49.7 |
100 99.4–100.0 |
100 99.4–100.0 |
88.5 87.0–89.9 |
| Rapid diagnostic test | 91 | 632 | 0 | 48 |
65.5 56.9–73.3 |
100 99.4–100.0 |
100 99.4–100.0 |
92.9 91.3–94.3 |
| crDNA-LAMP | 129 | 614 | 1 | 27 |
82.6 75.8–88.3 |
99.8 99.1–100.0 |
99.2 94.8–99.9 |
95.8 94.2–97.0 |
| pDNA-LAMP | 133 | 630 | 2 | 6 |
95.7 90.1–98.4 |
99.7 98.8–99.9 |
98.5 94.3–99.6 |
99.1 97.9–99.6 |
crDNA crude DNA extract, pDNA purified DNA extract, sWGA selective whole genome amplification, TP true positive, TN true negative, FP false positive, FN false negative, PPV positive predictive value, NPV negative predictive value