Fig. 1.

Study flowchart for the JACOB Chinese subpopulation. “Between study treatment and follow-up” refers to patients who have discontinued or completed study treatment but had not yet completed the first survival follow-up assessment. Patients in both treatment groups received trastuzumab, cisplatin, and fluoropyrimidine (capecitabine or 5-fluorouracil). *These patients were included in the intention-to-treat population. One patient assigned to the control group received one dose of pertuzumab in error and was included in the safety population for the pertuzumab group; the final safety population was consisted of 83 patients from the pertuzumab group and 80 patients from the control group