Table 2.

Univariate analysis and multivariate analysis of overall survival in the primary cohort (CGGA)

Variables	Univariate analysis			Multivariate analysis
	P value	HR	95% CI	P value	HR	95% CI
ARL3 level	< 0.0001	0.873	0.845–0.901	0.0095	0.949	0.913–0.987
Gender
Male	Reference			Reference
Female	0.345	0.847	0.60–1.195	0.7251	0.951	0.717–1.261
Age	< 0.0001	1.038	1.023–1.054	0.7727	1.002	0.987–1.018
WHO grade
Grade II	Reference			Reference
Grade III	< 0.0001	5.862	3.185–10.79	< 0.0001	4.508	2.395–8.486
Grade IV	< 0.0001	14.707	8.276–26.13	< 0.0001	8.658	4.578–16.377
IDH status
Wild type	Reference			Reference
Mutant	< 0.0001	0.244	0.17–0.35	0.1475	0.705	0.439–1.132