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. 2019 Jun 24;16:25. doi: 10.1186/s12989-019-0311-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Cardiac tissue fibrosis evaluation. Masson’s trichrome staining sections were analyzed by optical microscopy to evaluate perivascular and interstitial fibrosis in the LV myocardium (greenish). Representative images of heart sections from control (a and b) and TiO₂-NP treated animals (c and d). a CTRL LV myocardium; black rectangle area is shown at higher magnification in panel (b). c TiO₂-NPs treated LV myocardium; black rectangle area is shown at higher magnification in panel (d). Scale bars: a and c = 200 μm; b and d = 100 μm