Table 1.
Hemodynamic study
| CTRL (n = 9) | TiO2-NP (n = 11) | |
|---|---|---|
| Heart rate (beats/min) | 188 ± 5 | 190 ± 5 |
| Systolic arterial BP (mmHg) | 197.5 ± 2.12 | 198.16 ± 7.08 |
| Diastolic arterial BP (mmHg) | 122.4 ± 4.36 | 123.0 ± 4.92 |
| LVSP (mmHg) | 195.9 ± 2.90 | 195.4 ± 5.96 |
| LVEDP (mmHg) | 6.51 ± 0.55 | 8.32 ± 0.64* |
| +dP/dtmax (mmHg/s) | 9639.6 ± 86.37 | 8190.1 ± 264.5* |
| -dP/dtmax (mmHg/s) | − 7790.6 ± 117.7 | − 6608.2 ± 91.28* |
| IVCT (s) | 0.020 ± 0.0002 | 0.022 ± 0.0003* |
Values are means ± standard error of the mean (SEM)
Hemodynamic measurements were performed at 7th week, before sacrifice. Unpaired Student’s t-test
BP blood pressure, LVSP left ventricular systolic pressure, LVEDP left ventricular end-diastolic pressure, +dP/dtmax maximal rate of left ventricular (LV) pressure rise, −dP/dtmax maximal rate of LV pressure decline, IVCT isovolumic contraction time
*p < 0.05 vs CTRL