Table 2.
Tibial length, cardiac anatomy and morphometric analysis
| CTRL (n = 9) | TiO2-NP (n = 11) | |
|---|---|---|
| Tibial length (mm) | 38.2 ± 0.95 | 35.7 ± 0.25 * |
| BW (g) | 359.3 ± 6.47 | 356.1 ± 5.70 |
| LVW (mg) | 1200 ± 25.50 | 1119.13 ± 27.91 * |
| LVW/BW (mg/g) | 3.39 ± 0.10 | 3.16 ± 0.11 |
| LV mass (mm3) | 1132.1 ± 24.06 | 1055.8 ± 26.33 * |
| LV wall thickness (mm) | 2.28 ± 0.09 | 2.26 ± 0.06 |
| LV chamber diameter (mm) | 7.43 ± 0.40 | 7.68 ± 0.25 |
| LV chamber length (mm) | 15.44 ± 0.50 | 15.11 ± 0.42 |
| LV chamber volume (mm3) | 361.3 ± 38.16 | 469.3 ± 31.29 * |
| LV mass/chamber volume | 3.11 ± 0.33 | 2.39 ± 0.16 |
| Total fibrosis (%) | 7.64 ± 1.11 | 15.44 ± 3.09 * |
| Diffuse Fibrosis (%) | 4.24 ± 0.82 | 11.69 ± 3.18 * |
| Perivascular Fibrosis (%) | 3.59 ± 0.49 | 4.69 ± 0.45 |
Values are means ± SEM
Unpaired Student’s t-test
BW body weight measured before sacrifice, LV left ventricular, LVW left ventricular weight
*p < 0.05 vs CTRL