Table 3.
Comparison of perioperative factors in different surgical methods
| Mastectomy | BCS | X2 | P-value | |
|---|---|---|---|---|
| No. of patients | 49 | 31 | — | — |
| Anesthetic method | 0.016 | 0.899† | ||
| SEV | 23 (46.9) | 15 (48.4) | ||
| TIVA | 26 (53.1) | 16 (51.6) | ||
| Intraoperation opioids | ||||
| Remifentanil | 26 (53.1) | 16 (51.6) | 0.016 | 0.899† |
| Fentanyl | 36 (73.5) | 24 (77.4) | 0.158 | 0.691† |
| Postoperative analgesia | ||||
| Fentanyl | 2 (4.1) | 4 (12.9) | 1.048 | 0.306† |
| Flurbiprofen axetil (50mg) | 49 (100) | 31 (100) | — | — |
| Flurbiprofen axetil (100mg) | 7 (14.3) | 8 (25.8) | 1.654 | 0.198† |
| Serological indices | ||||
| Preoperative MDSCs (%) | 1.02 (0.67–2.17) | 1.25 (1.02–2.03) | — | 0.230* |
| PMN-MDSCs | 0.74 (−0.37–1.04) | 0.75 (0.57–1.20) | 0.390 | |
| Mo-MDSCs | 0.44 (0.19–1.18) | 0.53 (0.34–0.96) | 0.544 | |
| Postoperative MDSC (%) | 1.67 (1.15–3.92) | 2.93 (1.65–5.00) | — | 0.040* |
| PMN-MDSCs | 1.04 (0.68–1.61) | 1.18 (0.81–1.90) | 0.356 | |
| Mo-MDSCs | 0.88 (0.41–1.98) | 1.41 (0.64–3.06) | 0.351 | |
| Postoperative VAS | ||||
| VAS for 2 hrs | 2.0 (1.0–2.0) | 1.0 (0.0–2.0) | — | 0.108* |
| VAS for 24 hrs | 1.0 (1.0–2.0) | 2.0 (1.0–3.0) | — | 0.044* |
Notes: All data are presented as No. (%) or median (25–75% interquartile range), n=120. *Mann–Whitney test. †Chi-square (X2) test.
Abbreviations: BCS, breast-conserving surgery; SEV, sevoflurane-based anesthetic; TIVA, total intravenous anesthetic; Mo-MDSCs, monocytic myeloid-derived suppressor cells; PMN-MDSCs, polymorphonuclear myeloid-derived suppressor cells.