Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2019 Jun 25.

Published in final edited form as: Nat Rev Dis Primers. 2018 Dec 6;4(1):50. doi: 10.1038/s41572-018-0047-y

Table 2 |.

Ultrasonography criteria for an ADPKD diagnosis in at-risk individuals

Age	Genotype
	PKD1 mutation	PKD2 mutation	Unknown ADPKD genotype
15–30 years	• ≥3 cysts^a • PPV = 100% • SEN = 94.3%	• ≥3 cysts^a • PPV = 100% • SEN = 69.5%	• ≥3 cysts^a • PPV = 100% • SEN = 81.7%
30–39 years	• ≥3 cysts^a • PPV = 100% • SEN = 96.6%	• ≥3 cysts^a • PPV=100% • SEN = 94.9%	• ≥3 cysts^a • PPV=100% • SEN = 95.5%
40–59 years	• ≥2 cysts in each kidney • PPV = 100% • SEN = 92.6%	• ≥2 cysts in each kidney • PPV = 100% • SEN = 88.8%	• ≥2 cysts in each kidney • PPV = 100% • SEN = 90%

Compiled with data from Ref.¹⁶¹. ADPKD, autosomal dominant polycystic kidney disease; PPV, positive predictive value; SEN, sensitivity.

^a

Unilateral or bilateral. All values are mean estimates.