Table 1.

In vitro application of nano-curcumin

Nano-Cur	Cellular model	Disease	Key Finding	Ref.
Curcumin-loaded PLAG NPs	Neuroblastoma cell line (SK-N-SH cells)	AD	Inhibition of Nrf2, NF-kB and Akt phosphorylation Tau/↓ Expression of APOJ/↑ Expression of GLRX and TRX	45
g7-NPs-Cur	Primary hippocampal cell cultures/Aß (1–42)	AD	↓ Oxidative stress/↓ Inflammation/↓NF-kB/↑IkB//↑ Aß disaggregation	42
PLGA-PEG-B6/Cur	HT22 cells	AD	Narrowing the diameter of Cur/↑Cellular uptake	48
Alginate-curcumin nanocomposite (ACNC)	α-synuclein-induced cytotoxicity in SH-SY5Y neuroblastoma cells	PD	Apoptosis↓/Postpone the loss of climbing ability/Preventing caspase 3 activation/↓ Oxidative damage/↓ Cytotoxicity of accumulated α-synuclein	54
LF-NP-Cur	Rotenone-induced toxicity in SK-N-SH cells	PD	↓ ROS levels/Suppression of α-synuclein expression/↑ Expression of TH enzyme	53
GMO-NP-Piperine/Curcumin	Dopaminergic neurons against rotenone-induced degeneration model	PD	↓ Aggregation of α-synuclein/↓ Motor dysfunction/↓ Oxidative stress/↓ Apoptosis/Enhancing the autophagy/↑ Density of TH positive neurons	56
BSA-based nano-curcumin	6-hydroxydopamine (6-OHDA)-induced death and Akt signaling disruption in SH-SY5Y cells	PD	Corrected p-Akt/t-Akt signaling/prevent cell death	60
Curcumin and fish oil-loaded spongosome and cubosome NPs	H2O2-induced oxidative stress in differentiated human SH-SY5Y cells	PD	↓ H2O2-induced cell death/ ↓ ROS accumulation	58
Insulin-d-alpha-tocopherol succinate micelles (INVITE)–loaded curcumin micelles	Mesenchymal stromal cells (MSCs)	ALS	Maximum loading in MSCs/no cytotoxicity	79

Abbreviations: PLGA, Poly (lactic-co-glycolic acid); NPs, Nanoparticles; AD, Alzheimer’s disease; Cur, Curcumin; PEG, Polyethylene; PD, Parkinson’s disease; LF, Lactoferrin; ROS, Reactive oxygen species; TH, Tyrosine hydroxylase; GMO-NP, Glyceryl monooleate-nanoparticle; BSA, Bovine serum albumin; ALS, Amyotrophic lateral sclerosis.