Supplementary Table 1.
Univariate Cox regression analysis of chemokine family genes associated with overall survival in the training set (n=252, TCGA).
| Gene Symbol | Type | Sub-family | HR (95% CI) | Coefficient | p Value | Gene Symbol | Type | Sub-family | HR (95% CI) | Coefficient | p Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| CCL2 | Ligand | CC | 1.173 (1.019–1.351) | 0.16 | 0.026 | CXCL9 | Ligand | CXC | 0.966 (0.894–1.042) | −0.035 | 0.371 |
| CCL3 | Ligand | CC | 1.13 (0.978–1.305) | 0.122 | 0.097 | CXCL10 | Ligand | CXC | 1.006 (0.935–1.082) | 0.006 | 0.878 |
| CCL7 | Ligand | CC | 1.154 (1.027–1.296) | 0.143 | 0.016 | CXCL11 | Ligand | CXC | 1.028 (0.957–1.103) | 0.027 | 0.452 |
| CCL11 | Ligand | CC | 1.024 (0.916–1.146) | 0.024 | 0.671 | CXCL12 | Ligand | CXC | 1.054 (0.923–1.204) | 0.053 | 0.434 |
| CCL13 | Ligand | CC | 1.07 (0.952–1.203) | 0.068 | 0.256 | CXCL14 | Ligand | CXC | 0.956 (0.881–1.036) | −0.045 | 0.274 |
| CCL14 | Ligand | CC | 0.992 (0.897–1.097) | −0.008 | 0.876 | CXCL16 | Ligand | CXC | 1.079 (0.823–1.415) | 0.076 | 0.583 |
| CCL17 | Ligand | CC | 0.912 (0.796–1.044) | −0.092 | 0.183 | CXCL17 | Ligand | CXC | 0.933 (0.867–1.004) | −0.069 | 0.064 |
| CCL18 | Ligand | CC | 0.997 (0.896–1.109) | −0.003 | 0.954 | CXCR1 | Receptor | CXC | 0.997 (0.904–1.098) | −0.003 | 0.945 |
| CCL19 | Ligand | CC | 0.945 (0.875–1.021) | −0.056 | 0.153 | CXCR2 | Receptor | CXC | 0.917 (0.824–1.019) | −0.087 | 0.108 |
| CCL20 | Ligand | CC | 1.03 (0.948–1.12) | 0.03 | 0.48 | CXCR3 | Receptor | CXC | 0.909 (0.82–1.008) | −0.096 | 0.069 |
| CCL21 | Ligand | CC | 0.928 (0.858–1.004) | −0.075 | 0.063 | CXCR4 | Receptor | CXC | 0.871 (0.745–1.017) | −0.138 | 0.081 |
| CCL22 | Ligand | CC | 0.857 (0.746–0.985) | −0.154 | 0.03 | CXCR6 | Receptor | CXC | 0.886 (0.78–1.007) | −0.121 | 0.064 |
| CCL23 | Ligand | CC | 1.079 (0.912–1.275) | 0.076 | 0.375 | XCL1 | Ligand | XC | 0.959 (0.85–1.083) | −0.041 | 0.503 |
| CCL24 | Ligand | CC | 1 (0.876–1.143) | 0 | 0.997 | XCL2 | Ligand | XC | 0.856 (0.74–0.99) | −0.155 | 0.037 |
| CCL27 | Ligand | CC | 1.014 (0.891–1.155) | 0.014 | 0.83 | XCR1 | Receptor | XC | 0.831 (0.73–0.946) | −0.185 | 0.005 |
| CCL28 | Ligand | CC | 0.917 (0.801–1.049) | −0.087 | 0.207 | CX3CL1 | Ligand | CX3C | 1.008 (0.904–1.124) | 0.008 | 0.885 |
| CCR1 | Receptor | CC | 1.07 (0.928–1.233) | 0.067 | 0.352 | CX3CR1 | Receptor | CX3C | 0.859 (0.752–0.981) | −0.152 | 0.025 |
| CCR3 | Receptor | CC | 1.014 (0.816–1.261) | 0.014 | 0.899 | CXCL2 | Ligand | CXC | 1.062 (0.948–1.188) | 0.06 | 0.299 |
| CCR4 | Receptor | CC | 0.888 (0.8–0.985) | −0.119 | 0.025 | CXCL3 | Ligand | CXC | 1.074 (0.965–1.196) | 0.072 | 0.191 |
| CCR6 | Receptor | CC | 0.772 (0.652–0.915) | −0.258 | 0.003 | CXCL5 | Ligand | CXC | 1.113 (1.008–1.23) | 0.107 | 0.01 |
| CCR7 | Receptor | CC | 0.846 (0.752–0.951) | −0.167 | 0.005 | CXCL6 | Ligand | CXC | 1.053 (0.966–1.148) | 0.052 | 0.241 |
| CCR8 | Receptor | CC | 0.961 (0.849–1.088) | −0.039 | 0.533 | CXCL8 | Ligand | CXC | 1.14 (1.031–1.261) | 0.131 | 0.011 |
| CCR10 | Receptor | CC | 0.909 (0.785–1.052) | −0.096 | 0.201 |
CI – confidence index; HR – hazard ratio.