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. 2019 May 31;9(14):4084–4100. doi: 10.7150/thno.33638

Figure 8.

Figure 8

MSC-exos ameliorated the ER stress-related apoptosis and retarded the IDD progression in vivo. (A) X-ray of rat tail with three independent discs at 0, 4, 8 weeks. White, blue and red arrows mean discs with PBS, AGEs or AGEs and MSC-exos injection respectively. (B) T2-weighted MRI of rat tail at 0, 4, 8 weeks. White, blue and red arrows mean discs with PBS, AGEs or AGEs and MSC-exos injection respectively. (C-D) Changes in DHI (%DHI) (C) based on the X-ray and Pfirrmann MRI grades (D) based on the MRI results in each group (n = 20 for each group). Data were presented as the mean ± SD. *P < 0.05. (E) Representative HE staining and immunohistochemical staining of GRP78, CHOP and caspase-3 expression in each group. Magnification: 25 × (scar bar = 500 μm) and 200 × (scar bar = 50 μm). (F) Histological grades were assessed according to the HE staining (n = 20 for each group). Data were presented as the mean ± SD. *P < 0.05. (G-H) Representative TUNEL staining images (G) of rat discs and the statistical analysis (H) of TUNEL-positive cells in each group. Data were presented as the mean ± SD. *P < 0.05.