Figure 6.

Representative reconstructed aorta models in attenuation mode and correlation between signal intensity, diameter increase and burst pressure. A. 3D aorta models were reconstructed in attenuation mode for MS#1 (A1), MS#5 (A2), MS#11(A3) and control mouse (A4). The signal intensity shown in the suprarenal aortic segments decreases as elastin damage decreases. B. A strong negative nonlinear correlation between signal intensity and burst pressure was found using the power model (R²=0.9415, y = 20+08x^-3.586), while C. dilation vs. burst pressure and D. the circumferential Green-LaGrange strains vs. burst pressure were only weakly correlated with each other using the power-law, suggesting that the signal intensity induced by the accumulated degraded elastin targeting gold nanoparticles could serve as a better parameter to predict rupture potential than dilation.