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. 2019 Mar 28;170(1):157–166. doi: 10.1093/toxsci/kfz085

Figure 2.

Figure 2.

Ro 4-1284 treatment does not significantly affect peak body temperature but partially decreases body temperature AUC. Peak body temperature (A-B) and body temperature AUC (C-D). Graphs represent peak body temperature of (A) 20 mg/kg MDMA dose and (B) 27.5 mg/kg MDMA dose. Graphs represent body temperature AUC of (C) 20 mg/kg MDMA dose and (D) 27.5 mg/kg MDMA dose. AUC was calculated by a baseline body temperature set at the average of saline body temperature over the entire experiment. Values are different from the saline group at ***p < .001, ****p < .0001, and from MDMA group at ##p < .01.