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Ro 4-1284 co- and/or posttreatment does not protect against 3, 4-methylenedioxymethamphetamine (MDMA)-induced depletions in serotonin (5-HT) or 5-HIAA. 5-HT and 5-HIAA levels were measured in cortex and striatum of animals 7 days after treatment with Ro 4-1284 (10 mg/kg, ip) and/or MDMA (sc); (A) 20 mg/kg MDMA dose and (B) 27.5 mg/kg MDMA dose. Values are different from the saline group at *p < .01, **p < .001, ***p < .0001.
