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Saccharomyces cerevisiae Tor2 modeled onto human mTOR in the RHEB-binding pocket in mTORC1.
A homology model of ScTor2 (tan) built with SWISS-MODEL [55] based on the confirmation of mTOR (blue) in the cryo-EM-derived structure of mTORC1 occupied by GTPγS-bound RHEB (faint fuschia) (PDB: 6BCU) [46]. Side chains in human mTOR that make intermolecular contacts with RHEB (blue) and the corresponding side chains in yeast Tor2 (tan) are shown in stick representation.
