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HER2-L755S is highly resistant to both reversible and irreversible TKIs. (a and b) The dose response of indicated MCF10A cells to lapatinib treatment in monolayer for 4 days (a) and in soft-agar for 14 days (b). (c and d). The dose response of indicated MCF10A cells to neratinib treatment in monolayer for 4 days (c) and in soft-agar for 14 days (d). Data are expressed as means ± SEM. of three technical replicates.
