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. 2019 May 29;18(12):1379–1392. doi: 10.1080/15384101.2019.1618119

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Figure 3. — TRPV1 activation is required for capsaicin-induced mitochondrial dysfunction in human osteosarcoma MG63 cells. (a-c) Time course of capsaicin-induced reductions in MMP (a), complex I (b), and ATP levels (c). Significant effects were observed between 8 and 12 h following the capsaicin treatment. (d-f) Effects of capsazepine (Cpz) on capsaicin-induced decrease of MMP (d), complex I (e) and ATP (f), respectively. Blocking TRPV1 using Cpz attenuated the capsaicin-induced decrease in MMP, complex I activity and ATP content in MG63 cells. The values are expressed as the mean ± SD. *, p < 0.05, compared with control, #, p < 0.05, compared with capsaicin group.