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Polyploid hepatocytes protects the liver from mutagen-induced tumorigenesis.
Controlling liver polyploidization by manipulating weaning times or cytokinesis genes (i.e. Anln or E2f8) generated livers with different ploidy states. Induced polyploidization protected livers from mutagen-induced tumorigenesis while induced diploidization did the opposite. Figures adapted from [74].
